Orion may refer to:

• Orion (constellation), a constellation
• Orion Arm, a spiral arm in the Milky Way galaxy
• Orion Nebula, a nebula also known as M42
• Orion (US rocket), an American sounding rocket
• Orion (Argentine rocket), an Argentine sounding rocket
• Orion (spacecraft), a U.S. space capsule in development by Lockheed Martin, previously called the Crew Exploration Vehicle
• Orion, the lunar module of the Apollo 16 manned mission to the moon
• Project Orion, a proposed nuclear pulse propulsion system for spacecraft

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